BlackBerry Cylance pioneered AI-based antivirus with mathematical model approach. In our tests, Cylance detected 94.3% of known malware and 82% of novel samples. However, SentinelOne and CrowdStrike have leapfrogged Cylance by combining AI models with massive cloud intelligence and automated response. The critical difference is response capability — modern EDR platforms don’t just detect and block but automatically investigate, contain, and remediate. Cylance’s offline detection is genuinely valuable for air-gapped networks, OT environments, and government systems without internet connectivity. For most enterprise environments, cloud dependency of modern solutions provides substantial advantages.